HCLS/ClinicalObservationsInteroperability
< HCLS
COI Task Force
tasks
- Statistical proposed - aggregate clinical data
- FHIR current - RDF representation of FHIR resoruces, OWL representation of FHIR Schema.
- HL7 RIM
- Terminology
- ontology list current
- terminfo current - define equivalences and normal forms for clinical data expressible in either the information model (e.g. HL7/RIM) and terminology model (e.g. SNOMED-CT)
- Terminology Expressivity (representing value sets) current - what are the different ways terminologies are defined/described?
- Terminology Mapping Exchange current - system for sharing mappings between terminologies.
- CDISC current - leverage Roche's investment in RDF representations of CDISC standards.
- EMR + Clinical Trials completed 2010 - express clinical trial protocols as SPARQL queries and execute them on clinical RDBs.
- completed 2014 - FDA Therapeutic Area Ontologies current - documenting ericP and Charlie Mead's work on creating submission ontologies for FDA clinical trials.
Recent Meetings
Use Cases
Patient Recruitment
- EMR + Clinical Trials - A researcher inteface presented inputs for age, sex, medication/dosage inclusion and exclusion critera. The medications were expanded to include all drugs in their class. The interface produced a SPARQL query in a clinical research ontology. It was transformed to a query in a clinical care ontology, which was then transformed to a SQL query for a speclfic clinical care SQL schema.
Related Work
The proliferation of standards and research efforts reduces the efficiency with which we can meet practical use cases. Part of the mission here is to collaborate when possible, reducing later convergence costs.
Send mail to eric+COI@w3.org with suggestions, or join HCLS to edit directly.
Standards Bodies
Many standards break down into two categories; those that capture clinical events and the relationships between them, and those that precisely identify the medical or scientific basis for those events. For instance, CDA expreses a network of Observations with opaque codes which are taken from e.g. SNOMED, LOINC, etc.
Informational
- (Health Level 7)
- International standards for clinical data exchange.
- Message formats based on the Reference Information Model:
- CDA
- Clinical Document Architecture - XML expressions of Observations, Acts, relationships, etc.
- CCD
- Continuity of Care Document - profile of CCD intended to track an individual's medical encounters.
- CCDA
- Consolidated CDA - profile of CDA used in the Affordable Care Act's requirements for Meaningful Use.
- FHIR
- Fast Healthcare Interoperability Resources - a lighter-weight SOA and Web-compatible representation.
- Message formats based on the Reference Information Model:
- related: (TermInfo)
- Clinical Information Modeling Initiative
- Modeling clinical data in terms of openEHR archetypes.
Terminological
- SNOMED - (from IHTSDO) was pathology-related terms, but has grown enormously. SNOMED has an OWL Ontology capturing it's intricate hierarchy.
- LOINC - laboratory terms
- IDC9/10 - ontology of diseases, and procedures from the World Health Organization
- CPT - Current Procedural Terminology
- RxNorm - pharmaceutical drugs and delivery
- MedDRA - clinical trials (2005 tutorial)
European Initiatives
- (IMI) Innovative Medicines Initiative
- pre-competetive public/private parnership between EU and pharma (via EFPIA) running 2007-2017. Two foci:
- Efficacy Evaluation (for lung, prostate, ovarian, breast and colon cancers)
- PREDECT
- models for cancer treatments.
- ONCOTRACK
- biomarkers and response to cancer treatments.
- QUIC-CONCEPT
- biomarkers for cancer treatments.
- RAPP-ID
- point-of-care microbe detection, working with Q-Linea.
- SAFE-T
- kidney, liver and vascular drug safety/covigilance, working with EMA and FDA.
- BTCure
- cures for and intervention against rheumatoid arthritis.
- Knowledge Management for pharma research
- EHR4CR
- integration of EHRs for clincal research, use cases: e.g. patient recruitment, adverse event detection
- contact: Pierre-Yves Lastic, Sanofi
- DDMoRe
- modeling and simulation standards.
- OPEN-PHACTS
- SemWeb-based open-access drug discovery platform.
- contact: Egon Willighagen
- SALUS
- Standard-based interoperability framework for safety studies and analyzing real-time patient data.
- contact: Gokce Banu Laleci Erturkmen
- Efficacy Evaluation (for lung, prostate, ovarian, breast and colon cancers)
- related: (Pierre's overview)
- HealthGrid
- Grid for biomedical
- p-medicine
- VPH, personalized medicine (FP7-ICT-IP-270089, 2011-2015)
- contact: Stenzhorn, Holger, Benjamin Jefferys
- twobias
- Bio-threat surveillance
- DISCIPULUS
- ICT requirements for Digital VPH Patient
- (FP7/2007-2013)
- EUROCAT
- registries for logging births and congenital birth defects. Indexes about 1/4 of European births.
- Granatum - think tank for biomedical progress
- (EU funded project GRANATUM Biomedical Semantic Model)
- SemanticHeathNet (who)
- IT Future of Medicine (ITFoM) (integration blurb)
US Initiatives
- Indivo
- PCHRs in XML, working with Dossia
- Dossia
- PHR for employees
- CTS2
- clinical terminology standards
- I2B2
- mission
- projects
- SHRINE
- federated aggregate queries modeling inclusion and exclusion criteria
- GARLIC
- NGS variant analysis
- CRIMSON
- Bio-banking
- Health Ontology Mapper
- materialize integrations of multiple DBs.
- SMART
- substitutable medical apps.
- HITECH Act funding sources: