HCLS/IntegratedUseCase
< HCLS
Integrated Use Case
This wiki site contains the use case developed by June, Don and Helen by integrating the use cases available at:
- Parkinson's Disease by Don Doherty
- Alzheimer's Disease by June Kinoshita
- Clinical aspects of Parkinson's Disease by Helen Chen
Framework for AD/PD Integration
AD Use Case | |
Toxic Entity | Abeta*56 |
Parameters for Toxicity Characterization | Mol. wt., Moeity Status, macromolecular complex, etc. |
Target for Therapy | Abeta*56 |
Mechanism for Memory Loss | ?? |
Mechansim for LTP | ?? |
Relevant part of Brain | hippocampal neuron? |
Genes Implicated | INFG |
Type of Animal Model | Mouse |
Disruption Hypotheses | ADDL disrupts LTP? |
Channel Hypotheses | A-type, D-type Channels involved in LTP |
SNP Variations between mouse and human strains | Genes/SNPs involved?? |
Gene Regulation Knowledge | Enzymes/Gene networks involved in INFG regulation? |