HCLS/IntegratedUseCase
< HCLS
Integrated Use Case
This wiki site contains the use case developed by June, Don and Helen by integrating the use cases available at:
- Parkinson's Disease by Don Doherty
- Alzheimer's Disease by June Kinoshita
- Clinical aspects of Parkinson's Disease by Helen Chen
Framework for AD/PD Integration
| AD Use Case | |
| Toxic Entity | Abeta*56 |
| Parameters for Toxicity Characterization | Mol. wt., Moeity Status, macromolecular complex, etc. |
| Target for Therapy | Abeta*56 |
| Mechanism for Memory Loss | ?? |
| Mechansim for LTP | ?? |
| Relevant part of Brain | hippocampal neuron? |
| Genes Implicated | INFG |
| Type of Animal Model | Mouse |
| Disruption Hypotheses | ADDL disrupts LTP? |
| Channel Hypotheses | A-type, D-type Channels involved in LTP |
| SNP Variations between mouse and human strains | Genes/SNPs involved?? |
| Gene Regulation Knowledge | Enzymes/Gene networks involved in INFG regulation? |