<eneumann> scenario draft: http://esw.w3.org/topic/HCLSIG/Drug_Safety_and_Efficacy/Scenarios/Genetic_Diagnostic_CT#preview

linkage analysis for colon cancer contributors, would this be a whole genome scan or specific genes

probably do specific genotyping for cyp alleles

I should introduce Mike Swietek. He works at Pfizer and is in the office with me at the moment.

I'm just getting him familiar with the Zakim irc

<eneumann> says: Hi mike

<mswietek> Hello Eric, my web browser crashed

<eneumann> this should help... http://www.w3.org/2002/01/UsingZakim

<mswietek> Thanks

<eneumann> also if you're a tekkie... http://www.w3.org/2001/12/zakim-irc-bot.html

<mswietek> Thanks again

<eneumann> for the GeneChip, I assumed looking specifically at Cyp alleles rather than whole genome-- should be more practical?

Probably but by the time we get to Phase 11B we're pretty confident we know what metabolises our compound

so we'd go with a specfic genotype test more accurate than the gene chip

we'd use the genechip for exploratory work to look at other possible snps in teh pathway

or to subset populations based on safety information, I expect

I can run this senario past a few of our clinicians to modify it.

<eneumann> What is the name of the Affy-Roche CYP diagnostic chip?

amplichip I think

don't think we've used it

<mswietek> Amplichip CYP 450

<eneumann> thanks... Kerstin is calling me on my phone-- should be interesting!

If it's just Kerstin, you and us I can send out a conference number for us

<eneumann> That's all we need-- Bo can't make it.-- thanks!

Numbers have been mailed to you talk in a minute

<eneumann> ACTION: add CT data re-use steph #6 [recorded in http://www.w3.org/2007/04/13-dse1-minutes.html#action01]

<eneumann> ACTION: distinguish geno screening from gene analysis [recorded in http://www.w3.org/2007/04/13-dse1-minutes.html#action02]

<eneumann> set up TC with Stan Huff

<eneumann> ACTION: set up TC with Stan Huff [recorded in http://www.w3.org/2007/04/13-dse1-minutes.html#action03]

<eneumann> ACTION: put together DSE paper schedule [recorded in http://www.w3.org/2007/04/13-dse1-minutes.html#action04]

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