FDA Therapeutic Area strawman

<scribe> scribenick: ericP

-> http://www.w3.org/2013/12/FDA-TA/ strawman

charlie_: FDA said the focus on the TA work is efficacy points
... obsevations connecting intervention and pathophysioly
... obs: normal, outcomes, endpoints

<kerstin> Charlie talking through http://www.w3.org/2013/12/FDA-TA/TA-MetaModel-cmap.png

charlie_: metamodel is the above model

ericP: bottom-up abuse of the metamodel, coopted for base classes

-> http://www.w3.org/2014/Talks/0107-FDA-TA-egp/#(4)

http://www.w3.org/2014/Talks/0107-FDA-TA-egp/#(2)

http://www.w3.org/2014/Talks/0107-FDA-TA-egp/#(2)

Claude: i think of observations as quantitative measurements and the thing i do the make the observations
... unless obs really means the act of observing, and the result is captured elsewhere, this model is potentally confusing
... coulld separate the act of observing from the data observed

charlie_: in early RIM, there was a separation. now Obs is a kind of Act with a code.
... RIM has substance administration etc.
... FDA cares about processes as measured by some generic idea of the value of the obs

Claude: i'm working on models for CDS

charlie_: FDA is not trying to feed CDS, instead just looking at the evidence around effectiveness of intervention

Claude: we're looking at a CDS ontology, could we interop with this?

charlie_: we asked that it all be sharable, but note that this will be narrow

ericP: is the distinction useful in CDS?

Claude: HL7's model for CDS is the Virtual Medical Record
... a CDS rule might look at a set of characteristics about a patient and fire off a diagnostic procedure

Sajjad: have you written formal dens?

charlie_: FDA knows they have to do it

-> http://www.w3.org/2013/12/FDA-TA/ strawman

ericP: can two people use variations of a ontology and get useful data interop

http://www.w3.org/2014/Talks/0107-FDA-TA-egp/

-> http://www.w3.org/2013/12/FDA-TA/ strawman

charlie: expect ta-specific, ta-group (e.g. commonalities at organ level or systemic processes like inflamation), and pan-ta
... we need to show FDA that common semantics across TAs will be recognizable

Mike: Q: about Obs -[ AtomicObs, OutcomeAssessment ]

-> http://www.w3.org/2013/12/FDA-TA/subject-amy.ttl amy gets better

# Positive outcome

:subjectsKidneyGraftWithNormalFunction a rrej:KidneyGraftOutcomeAssessment ; # a rrej:GraftSurvival ;

mm: hasObservationTime "2013-10-19T12:34:00Z"^^xsd:dateTime ;
... beforeIntervention :subjectsOutpatientGFR10 , :subjectsGFRpreOp ;
... intervention :subjectOnExcipiens , :subjectsTransplant ;
... afterIntervention :subjectsPostOpDay5GFR ;
... hasOutcomeValue rrej:NormalFunctioningGraft .

Claude: re-usable in the clinical practice feedback loop

charlie_: determining efficacy of interventions may well require the granularity that Claude alluded to before.

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Found ScribeNick: ericP
Inferring Scribes: ericP
Default Present: ericP, +1.919.767.aaaa, TimWilliams, Mike_Denny, Kerstin_Forsberg, charlie, Sajjad, claude
Present: ericP +1.919.767.aaaa TimWilliams Mike_Denny Kerstin_Forsberg charlie Sajjad claude

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Got date from IRC log name: 14 Jan 2014
Guessing minutes URL: http://www.w3.org/2014/01/14-hcls-minutes.html
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