For example, an enveloped signature on the rest of the document:
<Document id="Full">
<Signature xmlns:dsig="...">
<SignedInfo>
<Reference Id="#Full">
<Transform Algorithm="..">
<XPath>not(ancestor-or-self::dsig:Signature)</XPath>
</Transform>
</Reference>
...
</SignedInfo>
</Signature>
...
</Document>