HCLS/ClinicalObservationsInteroperability
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* [[/EMR_CT|EMR + Clinical Trials]] - A researcher inteface presented inputs for age, sex, medication/dosage inclusion and exclusion critera. The medications were expanded to include all drugs in their class. The interface produced a SPARQL query in a clinical research ontology. It was transformed to a query in a clinical care ontology, which was then transformed to a SQL query for a speclfic clinical care SQL schema. | * [[/EMR_CT|EMR + Clinical Trials]] - A researcher inteface presented inputs for age, sex, medication/dosage inclusion and exclusion critera. The medications were expanded to include all drugs in their class. The interface produced a SPARQL query in a clinical research ontology. It was transformed to a query in a clinical care ontology, which was then transformed to a SQL query for a speclfic clinical care SQL schema. | ||
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| + | * Eureka - | ||
| + | * Linked2Safety - | ||
| + | * EHR4CR - | ||
= Related Work = | = Related Work = | ||
Revision as of 16:02, 24 January 2013
COI Task Force
tasks
- terminfo current - define equivalences and normal forms for clinical data expressible in either the information model (e.g. HL7/RIM) and terminology model (e.g. SNOMED-CT)
- HL7/RIM current - OWL representation of the RIM's MIF.
- CDISC current - leverage Roche's investment in RDF representations of CDISC standards.
- EMR + Clinical Trials completed 2010 - express clinical trial protocols as SPARQL queries and execute them on clinical RDBs.
Use Cases
Patient Recruitment
- EMR + Clinical Trials - A researcher inteface presented inputs for age, sex, medication/dosage inclusion and exclusion critera. The medications were expanded to include all drugs in their class. The interface produced a SPARQL query in a clinical research ontology. It was transformed to a query in a clinical care ontology, which was then transformed to a SQL query for a speclfic clinical care SQL schema.
- Eureka -
- Linked2Safety -
- EHR4CR -
Related Work
European Initiatives
- (IMI) Innovative Medicines Initiative
- pre-competetive public/private parnership between EU and pharma (via EFPIA) running 2007-2017. Two foci:
- Efficacy Evaluation (for lung, prostate, ovarian, breast and colon cancers)
- PREDECT
- models for cancer treatments.
- ONCOTRACK
- biomarkers and response to cancer treatments.
- QUIC-CONCEPT
- biomarkers for cancer treatments.
- RAPP-ID
- point-of-care microbe detection, working with [1].
- SAFE-T
- kidney, liver and vascular drug safety/covigilance, working with EMA and FDA.
- BTCure
- cures for and intervention against rheumatoid arthritis.
- Knowledge Management for pharma research
- EHR4CR
- integration of EHRs for clincal research, use cases: e.g. patient recruitment, adverse event detection
- contact: Pierre-Yves Lastic, Sanofi
- DDMoRe
- modeling and simulation standards.
- OPEN-PHACTS
- SemWeb-based open-access drug discovery platform.
- contact: Egon Willighagen
- related: (Pierre's overview)
- Efficacy Evaluation (for lung, prostate, ovarian, breast and colon cancers)
- HealthGrid
- Grid for biomedical
- p-medicine
- VPH, personalized medicine (FP7-ICT-IP-270089, 2011-2015)
- contact: Stenzhorn, Holger, Benjamin Jefferys
- twobias
- Bio-threat surveillance
- DISCIPULUS
- ICT requirements for Digital VPH Patient
- (FP7/2007-2013)
- EUROCAT
- registries for logging births and congenital birth defects. Indexes about 1/4 of European births.
- Granatum - think tank for biomedical progress
- (EU funded project GRANATUM Biomedical Semantic Model)
- SemanticHeathNet (who)
- IT Future of Medicine (ITFoM) (integration blurb)
US Initiatives
- Indivo
- PCHRs in XML, working with Dossia
- Dossia
- PHR for employees
- I2B2
- mission
- projects
- SHRINE
- federated aggregate queries modeling inclusion and exclusion criteria
- GARLIC
- NGS variant analysis
- CRIMSON
- Bio-banking
- Health Ontology Mapper
- materialize integrations of multiple DBs.
- SMART
- substitutable medical apps.
- HITECH Act
funding sources:
