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{
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"fromtitle": "HCLS/ParkinsonUseCase",
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"torevid": 2,
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"totitle": "HCLS/ParkinsonUseCase",
"*": "<tr><td colspan=\"2\" class=\"diff-lineno\" id=\"mw-diff-left-l1\">Line 1:</td>\n<td colspan=\"2\" class=\"diff-lineno\">Line 1:</td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>__NOTOC__</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>__NOTOC__</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\"><!-- ## page was renamed from HCLS/OntologyTaskForce/ParkinsonUseCase --></ins></div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\"><!-- ## page was renamed from HCLSIGUseCases/ParkinsonUseCase --></ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>{| border="1" cellpadding="2" cellspacing="0"</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>{| border="1" cellpadding="2" cellspacing="0"</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[[HCLSIG|HCLS Home]]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [[HCLSIG|HCLS Home]]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[[HCLS/OntologyTaskForce|OTF Home]]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [[HCLS/OntologyTaskForce|OTF Home]]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[http://lists.w3.org/Archives/Public/public-semweb-lifesci/ Discussions]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [http://lists.w3.org/Archives/Public/public-semweb-lifesci/ Discussions]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[mailto:public-semweb-lifesci@w3.org Post to HCLS listserv]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [mailto:public-semweb-lifesci@w3.org Post to HCLS listserv]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[[HCLS/OntologyTaskForce/Telcons|Minutes]]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [[HCLS/OntologyTaskForce/Telcons|Minutes]]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[[HCLS/OntologyTaskForce/UsefulLinks|Links]]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [[HCLS/OntologyTaskForce/UsefulLinks|Links]]</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>|}</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>|}</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\"></ins></div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\"><br><br></ins></div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">{| border=\"1\" cellpadding=\"2\" cellspacing=\"0\"</ins></div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">|}</ins></div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\"><br><br></ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>== Parkinson\u2019s Disease Use Cases ==</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>== Parkinson\u2019s Disease Use Cases ==</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">Two </del>views of Parkinson\u2019s disease are outlined below. They <del class=\"diffchange diffchange-inline\">both </del>address the same disease but at different levels of <del class=\"diffchange diffchange-inline\">biological </del>abstraction<del class=\"diffchange diffchange-inline\">. Perhaps systems physiology is like programming in [[SmallTalk]] while cellular </del>and <del class=\"diffchange diffchange-inline\">molecular biology are programming in assembly and machine language.</del></div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">Several </ins>views of Parkinson\u2019s disease are outlined below. They address the same disease but at different levels of abstraction and <ins class=\"diffchange diffchange-inline\">under different agendas</ins>.</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div>\u00a0</div></td><td colspan=\"2\" class=\"diff-side-added\"></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">Both views are very simplified but should give a flavor</del>.</div></td><td colspan=\"2\" class=\"diff-side-added\"></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>=== Systems Physiology View ===</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>=== Systems Physiology View ===</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-lineno\" id=\"mw-diff-left-l25\">Line 25:</td>\n<td colspan=\"2\" class=\"diff-lineno\">Line 30:</td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>At the systems physiology level it is the balance of activity between the indirect and direct pathways from the striatum to the pallidum that at one extreme leads to Parkinson\u2019s disease (over-activity in the indirect pathway results in over-inhibited, or not enough, movement) and at the other extreme leads to Huntington\u2019s disease (over-activity in the direct pathway results in too much movement).</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>At the systems physiology level it is the balance of activity between the indirect and direct pathways from the striatum to the pallidum that at one extreme leads to Parkinson\u2019s disease (over-activity in the indirect pathway results in over-inhibited, or not enough, movement) and at the other extreme leads to Huntington\u2019s disease (over-activity in the direct pathway results in too much movement).</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">_Systems </del>neurophysiologists try to learn more about the normal functioning of these circuits and their malfunction in Parkinson\u2019s disease by asking questions like:<del class=\"diffchange diffchange-inline\">_</del></div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">''Systems </ins>neurophysiologists try to learn more about the normal functioning of these circuits and their malfunction in Parkinson\u2019s disease by asking questions like:<ins class=\"diffchange diffchange-inline\">''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What are the wiring diagrams of the brain systems?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What are the wiring diagrams of the brain systems?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Brain, System Model of Brain, Wiring Diagram of System Model of Brain'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What chemicals (neurotransmitters) are used by each circuit element (neuron) to communicate with the next element (neuron)? What responses do they elicit in the neurons?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What chemicals (neurotransmitters) are used by each circuit element (neuron) to communicate with the next element (neuron)? What responses do they elicit in the neurons?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Chemical, Neurotransmitter (subtype of Chemical), Circuit Element of System Model of Brain, Neuron, Communicates With'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What proteins (receptors) recognize those chemicals (neurotransmitters) and what are the responses that they elicit in the neuron?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What proteins (receptors) recognize those chemicals (neurotransmitters) and what are the responses that they elicit in the neuron?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Receptors, Proteins (subtype of Receptors), Recognizes, Response_Elicited'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What are the response properties of a particular kind of neuron in a particular part of the brain to particular input?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What are the response properties of a particular kind of neuron in a particular part of the brain to particular input?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Properties of response, Part of Brain'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What is the \u201cneuronal code?\u201d How is it transformed? What information does it contain?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What is the \u201cneuronal code?\u201d How is it transformed? What information does it contain?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Code of Neuron, Information contained in Code of Neuron, Transformed_To'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>=== Cellular and Molecular Biologist View ===</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>=== Cellular and Molecular Biologist View ===</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-lineno\" id=\"mw-diff-left-l41\">Line 41:</td>\n<td colspan=\"2\" class=\"diff-lineno\">Line 51:</td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>Studies of genetic linkages, specific genes, and their associated coded proteins are ongoing in the Parkinson's disease research field. Mutations in the Parkin gene cause early onset Parkinson's disease, and the parkin protein has been identified as an E3 ligase, suggesting a role for the proteasomal pathway of protein degradation in Parkinson's disease. DJ-1 and PINK-1 are proteins related to mitochondrial function in neurons, providing an interesting genetic parallel to mitochondrial toxin studies that suggest disruptions in cellular energetics and oxidative metabolism are primarily responsible for Parkinson's disease. Other genes, such as UCHL-1, tau, and the glucocerebrosidase gene, may be genetic risk factors, and their potential role in the sporadic Parkinson's disease population remains unknown. Mutations in LRRK2, which encodes for a protein called dardarin, is the most recently discovered genetic cause of Parkinson's disease, and LRRK2 mutations are likely to be the largest cause of familial Parkinson's disease identified thus far. Dardarin is a large complex protein, which has a variety of structural moieties that could be participating in more than a dozen different cellular pathways in neurons. Because the cellular pathways that lead to Parkinson's disease are not fully understood, it is currently unknown, how, or if, any of these pathways intersect in Parkinson's disease pathogenesis.</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>Studies of genetic linkages, specific genes, and their associated coded proteins are ongoing in the Parkinson's disease research field. Mutations in the Parkin gene cause early onset Parkinson's disease, and the parkin protein has been identified as an E3 ligase, suggesting a role for the proteasomal pathway of protein degradation in Parkinson's disease. DJ-1 and PINK-1 are proteins related to mitochondrial function in neurons, providing an interesting genetic parallel to mitochondrial toxin studies that suggest disruptions in cellular energetics and oxidative metabolism are primarily responsible for Parkinson's disease. Other genes, such as UCHL-1, tau, and the glucocerebrosidase gene, may be genetic risk factors, and their potential role in the sporadic Parkinson's disease population remains unknown. Mutations in LRRK2, which encodes for a protein called dardarin, is the most recently discovered genetic cause of Parkinson's disease, and LRRK2 mutations are likely to be the largest cause of familial Parkinson's disease identified thus far. Dardarin is a large complex protein, which has a variety of structural moieties that could be participating in more than a dozen different cellular pathways in neurons. Because the cellular pathways that lead to Parkinson's disease are not fully understood, it is currently unknown, how, or if, any of these pathways intersect in Parkinson's disease pathogenesis.</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">_Cellular </del>and molecular neurobiologists ask:<del class=\"diffchange diffchange-inline\">_</del></div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">''Cellular </ins>and molecular neurobiologists ask:<ins class=\"diffchange diffchange-inline\">''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What proteins are implicated in Parkinson's disease? How are protein expression patterns, protein processing, folding, regulation, transport, protein-protein interactions, protein degradation, etc. affected?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What proteins are implicated in Parkinson's disease? How are protein expression patterns, protein processing, folding, regulation, transport, protein-protein interactions, protein degradation, etc. affected?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Disease, Proteins implicated in disease, Expression pattern of protein, protein processing result, protein folding result, protein regulation result, interacts_with'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What cell signaling pathways are implicated in the pathogenesis of Parkinson\u2019s disease? In which cells? What proteins are involved in which pathways?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What cell signaling pathways are implicated in the pathogenesis of Parkinson\u2019s disease? In which cells? What proteins are involved in which pathways?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Cell, signaling pathway of cell, Pathogenesis of disease, Implicated_in, Involved_in'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* Are there any potential biomarkers for Parkinson's disease based on these proteins?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* Are there any potential biomarkers for Parkinson's disease based on these proteins?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Biomarkers of Disease, Protiens associated with Biomarkers of Disease'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>=== Clinical Researcher View ===</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>=== Clinical Researcher View ===</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-lineno\" id=\"mw-diff-left-l51\">Line 51:</td>\n<td colspan=\"2\" class=\"diff-lineno\">Line 64:</td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>Clinical researchers, including both academic and commercial investigators, make use of knowledge generated by basic scientists in order to evaluate approaches to diagnosing and treating Parkinson\u2019s disease that are superior to existing approaches.</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>Clinical researchers, including both academic and commercial investigators, make use of knowledge generated by basic scientists in order to evaluate approaches to diagnosing and treating Parkinson\u2019s disease that are superior to existing approaches.</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">_Clinical </del>researchers ask:<del class=\"diffchange diffchange-inline\">_</del></div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">''Clinical </ins>researchers ask:<ins class=\"diffchange diffchange-inline\">''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* Can a certain diagnostic test (e.g., a blood test for a biomarker or an imaging study) provide an approach to diagnosing Parkinson\u2019s disease that is superior to or can complement existing diagnostic approaches?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* Can a certain diagnostic test (e.g., a blood test for a biomarker or an imaging study) provide an approach to diagnosing Parkinson\u2019s disease that is superior to or can complement existing diagnostic approaches?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Diagnostic test, blood test (subtype of diagnostic test), imaging study (subtype of diagnostic test), Test Associated With Disease'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* Can a certain therapeutic intervention (e.g., a drug targeted at a protein implicated in the pathogenesis of the disease) provide an approach to treating Parkinson\u2019s disease that is superior to or can complement existing diagnostic approaches?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* Can a certain therapeutic intervention (e.g., a drug targeted at a protein implicated in the pathogenesis of the disease) provide an approach to treating Parkinson\u2019s disease that is superior to or can complement existing diagnostic approaches?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Therapeutic intervention, Intervention Treats Diseases'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What are the side effects and costs associated with these diagnostic and therapeutic interventions?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What are the side effects and costs associated with these diagnostic and therapeutic interventions?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Cost of Intervention, Effect of Intervention, Diagnostic intervention (subtype of intervention), Therapeutic intervention (subtype of intervention)'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>=== Clinical Guideline Formulator View ===</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>=== Clinical Guideline Formulator View ===</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-lineno\" id=\"mw-diff-left-l61\">Line 61:</td>\n<td colspan=\"2\" class=\"diff-lineno\">Line 77:</td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>Academic researchers and professional societies synthesize the available evidence regarding the diagnosis and management of Parkinson\u2019s disease to generate human-readable clinical guidelines.\u00a0 A similar process may also be used to formulate the content for clinical texts.</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>Academic researchers and professional societies synthesize the available evidence regarding the diagnosis and management of Parkinson\u2019s disease to generate human-readable clinical guidelines.\u00a0 A similar process may also be used to formulate the content for clinical texts.</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">_Clinical </del>guideline formulators ask:<del class=\"diffchange diffchange-inline\">_</del></div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">''Clinical </ins>guideline formulators ask:<ins class=\"diffchange diffchange-inline\">''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What have been the results of clinical trials that have evaluated the benefits and costs associated with diagnostic or therapeutic interventions for Parkinson\u2019s disease?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What have been the results of clinical trials that have evaluated the benefits and costs associated with diagnostic or therapeutic interventions for Parkinson\u2019s disease?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Clinical Trial, Result of Clinical Trial, Benefit of Intervention, Intervention for Disease'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* How were these clinical trials conducted?\u00a0 For example, were they conducted as double-blind randomized controlled trials?\u00a0 What was the sample size?\u00a0 Was the trial adequately powered? \u00a0</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* How were these clinical trials conducted?\u00a0 For example, were they conducted as double-blind randomized controlled trials?\u00a0 What was the sample size?\u00a0 Was the trial adequately powered? \u00a0</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Type of clinical trial, Sample Size of Clinical Trial, Power of Clinical Trial'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What recommendations can be made to clinicians based on the results of these clinical trials?\u00a0 How strong is the evidence for these recommendations?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What recommendations can be made to clinicians based on the results of these clinical trials?\u00a0 How strong is the evidence for these recommendations?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Results of Clinical Trial, Recommendation base on Results of Clinical Trials, Evidence Strength for recommendation'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>=== Clinical Decision Support System Implementer View ===</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>=== Clinical Decision Support System Implementer View ===</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-lineno\" id=\"mw-diff-left-l71\">Line 71:</td>\n<td colspan=\"2\" class=\"diff-lineno\">Line 90:</td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>Implementers of clinical decision support (CDS) systems (systems that make use of patient data to provide patient-specific assessments or recommendations to clinicians to assist with clinical decision making) encode knowledge regarding the diagnosis and/or treatment of Parkinson\u2019s disease into a format that can be used to provide CDS.\u00a0 How the knowledge is represented depends on a number of factors, including: (1) the IT environment in which the CDS is to be provided; (2) the CDS execution architecture to be used; (3) whether the CDS system provides the advice to clinicians as part of their clinical workflow or responds to active requests from clinicians to provide advice; and (4) whether the CDS system can ask question to a human user to obtain the information necessary to provide the CDS.</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>Implementers of clinical decision support (CDS) systems (systems that make use of patient data to provide patient-specific assessments or recommendations to clinicians to assist with clinical decision making) encode knowledge regarding the diagnosis and/or treatment of Parkinson\u2019s disease into a format that can be used to provide CDS.\u00a0 How the knowledge is represented depends on a number of factors, including: (1) the IT environment in which the CDS is to be provided; (2) the CDS execution architecture to be used; (3) whether the CDS system provides the advice to clinicians as part of their clinical workflow or responds to active requests from clinicians to provide advice; and (4) whether the CDS system can ask question to a human user to obtain the information necessary to provide the CDS.</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">_CDS </del>system implementers ask:<del class=\"diffchange diffchange-inline\">_</del></div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">''CDS </ins>system implementers ask:<ins class=\"diffchange diffchange-inline\">''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* Is there a problem in how clinicians are currently diagnosis and/or treating Parkinson\u2019s disease?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* Is there a problem in how clinicians are currently diagnosis and/or treating Parkinson\u2019s disease?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Clinician, Clinician makes Diagnosis, Clinician treats Disease'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* When and how should the CDS be provided to clinicians in order to assist with the diagnosis and/or treatment of Parkinson\u2019s disease?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* When and how should the CDS be provided to clinicians in order to assist with the diagnosis and/or treatment of Parkinson\u2019s disease?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Not sure ...'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* Which clinical guideline(s) should be used as the basis for implementing the CDS functionality?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* Which clinical guideline(s) should be used as the basis for implementing the CDS functionality?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Clinical Guideline, Clinical Decision Support Rules, Rules based on Clinical Guideline'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* What information model should be used to represent the relevant data elements (e.g., symptoms, biomarkers, image results), and what terminologies (e.g., SNOMED CT, ICD9, LOINC) should be used to identify clinical concepts?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* What information model should be used to represent the relevant data elements (e.g., symptoms, biomarkers, image results), and what terminologies (e.g., SNOMED CT, ICD9, LOINC) should be used to identify clinical concepts?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Metadata information related to the controlled terminology and information model used'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>=== Primary Care Clinician View ===</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>=== Primary Care Clinician View ===</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-lineno\" id=\"mw-diff-left-l82\">Line 82:</td>\n<td colspan=\"2\" class=\"diff-lineno\">Line 105:</td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>A primary care clinician would typically manage a patient with Parkinson\u2019s disease in collaboration with a neurologist.\u00a0 A primary care clinician may be able to find the time to consult information resources, although the literature indicates that most clinical questions remain unanswered in routine clinical practice.</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>A primary care clinician would typically manage a patient with Parkinson\u2019s disease in collaboration with a neurologist.\u00a0 A primary care clinician may be able to find the time to consult information resources, although the literature indicates that most clinical questions remain unanswered in routine clinical practice.</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">_Primary </del>care clinicians ask:<del class=\"diffchange diffchange-inline\">_</del></div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">''Primary </ins>care clinicians ask:<ins class=\"diffchange diffchange-inline\">''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* If a patient is not currently diagnosed with Parkinson\u2019s disease, do the patient\u2019s current symptoms indicate the need for further diagnostic evaluation within the primary care setting?\u00a0 If so, what further evaluation is required?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* If a patient is not currently diagnosed with Parkinson\u2019s disease, do the patient\u2019s current symptoms indicate the need for further diagnostic evaluation within the primary care setting?\u00a0 If so, what further evaluation is required?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\">\u00a0 '''Concepts of interest: Patient, Patient diagnosed with Disease, Current Symptoms of Patient, Evaluation of Patient'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* If a patient is not currently diagnosed with Parkinson\u2019s disease, do the patient\u2019s current symptoms indicate the need for a referral to a neurologist for further evaluation?\u00a0 If so, what are the referral criteria?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* If a patient is not currently diagnosed with Parkinson\u2019s disease, do the patient\u2019s current symptoms indicate the need for a referral to a neurologist for further evaluation?\u00a0 If so, what are the referral criteria?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange\"> '''Concepts of interest: Referral for Patient, Referral Criteria for Patient'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>* If a patient is currently diagnosed with Parkinson\u2019s disease, does the patient have any symptoms or signs that indicate the patient\u2019s current management plan for Parkinson\u2019s disease (as formulated by a neurologist) is in need of change?</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>* If a patient is currently diagnosed with Parkinson\u2019s disease, does the patient have any symptoms or signs that indicate the patient\u2019s current management plan for Parkinson\u2019s disease (as formulated by a neurologist) is in need of change?</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div>Neurologist View</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">\u00a0 '''Concepts of interest: Management Plan for Patient'''</ins></div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>\u00a0</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">=== </ins>Neurologist View <ins class=\"diffchange diffchange-inline\">===</ins></div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>\u00a0</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>Neurologists work with primary care clinicians to manage patients with Parkinson\u2019s disease.\u00a0 \u00a0</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>Neurologists work with primary care clinicians to manage patients with Parkinson\u2019s disease.\u00a0 \u00a0</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div>Neurologists ask:</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">''</ins>Neurologists ask:<ins class=\"diffchange diffchange-inline\">''</ins></div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">\u2022\t</del>What is the differential diagnosis for this patient given his/her symptoms, signs, and diagnostic test results?</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>\u00a0</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">\u2022\t</del>What diagnostic intervention is indicated next given the current state of knowledge regarding the patient?</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">* </ins>What is the differential diagnosis for this patient given his/her symptoms, signs, and diagnostic test results?</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">\u2022\t</del>What management plan is indicated for this patient?</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">\u00a0 '''Concepts of Interest: Differential Diagnosis for Patient'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">\u2022\t</del>What are the costs and benefits associated with each treatment option?</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">* </ins>What diagnostic intervention is indicated next given the current state of knowledge regarding the patient?</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">\u2022\t</del>What is the prognosis for this patient?</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">* </ins>What management plan is indicated for this patient?</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">\u2022\t</del>Is the current management plan optimal for the patient?</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">* </ins>What are the costs and benefits associated with each treatment option?</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">Some Use Cases</del></div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">\u00a0 '''Concepts of interest: Cost of Therapy, Benefit of Therapy'''</ins></div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">These use cases are applicable to most research into brain functions and disease.</del></div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">* </ins>What is the prognosis for this patient?</div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">\u00a0 '''Concepts of interest: Prognosis for Patient'''</ins></div></td></tr>\n<tr><td colspan=\"2\" class=\"diff-side-deleted\"></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div><ins class=\"diffchange diffchange-inline\">* </ins>Is the current management plan optimal for the patient?</div></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><br></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><br></td></tr>\n<tr><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-deleted\"><div>{| border="1" cellpadding="2" cellspacing="0"</div></td><td class=\"diff-marker\"></td><td class=\"diff-context diff-side-added\"><div>{| border="1" cellpadding="2" cellspacing="0"</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[[HCLSIG|HCLS Home]]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [[HCLSIG|HCLS Home]]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[[HCLS/OntologyTaskForce|OTF Home]]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [[HCLS/OntologyTaskForce|OTF Home]]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[http://lists.w3.org/Archives/Public/public-semweb-lifesci/ Discussions]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [http://lists.w3.org/Archives/Public/public-semweb-lifesci/ Discussions]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[mailto:public-semweb-lifesci@w3.org Post to HCLS listserv]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [mailto:public-semweb-lifesci@w3.org Post to HCLS listserv]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[[HCLS/OntologyTaskForce/Telcons|Minutes]]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [[HCLS/OntologyTaskForce/Telcons|Minutes]]</div></td></tr>\n<tr><td class=\"diff-marker\" data-marker=\"\u2212\"></td><td class=\"diff-deletedline diff-side-deleted\"><div><del class=\"diffchange diffchange-inline\">|<#D8D8D8></del>|[[HCLS/OntologyTaskForce/UsefulLinks|Links]]</div></td><td class=\"diff-marker\" data-marker=\"+\"></td><td class=\"diff-addedline diff-side-added\"><div>| [[HCLS/OntologyTaskForce/UsefulLinks|Links]]</div></td></tr>\n"
}
}