HCLSIG/PharmaOntology/Meetings/2011-04-21 Conference Call/minutes

minutes recorded by Joanne

Recording from today's HCLS Telcon (4/21/2011; CollabRx)

Dr. Jeff Shrager (Co-Founder and Chief Technology Officer of CollabRx and Consulting Associate Professor at Stanford University) who will talk to us about the work being done at CollabRx. You might be interesting in reading one of his papers that he provided to us, which will appear in the next issue of AI magazine (temporarily available at http://dumontierlab.com/temp/CCAAAI.pdf).

Molecular Disease Models (MDM)

Melanoma (MMDM)

Targeted Therapy Finder

Molecular (Melanoma) Cancer therapy finder, need to get tested, then will show trials, different then clinicaltrials.gov, this is highly curated by leading experts in melanoma. About 12 total lead in melanoma / expert sourcing / help build model, which results in limited trials - those selected by the experts as highly relevant trials.

Semantic Media Wiki

Started to not be a "Trial finder" - too many questions, too many responses

Finding from docs -- trials used to send people to, also used as kind of publication, look at what's going on in the field.

Here - not total num of trials, but only ones most relevant, as deemed by experts.

The short tables, to give you "mind sized" and not get overwhelmed. Doc can Grok

George: Open Source Science in Real time (anyone can go here)

collabrx.com

cancercommons.org

open access in pubmed central

encode review papers rather than scientific knowledge A Melanoma Molecular Disease Model PLoS One, Vidwans et al. Set up by MIke Travers

While Scientific papers have methods sections, Review should have Implementation Sections (their paper does)

no building for lung cancer, colorectal cancer, and others

Idea is that an oncologist can read and understand makes the model viable...

Questions asked: Who did this? Where are they? Then scientific basis.

learn, test, treat, analyze loop table on targeted therapy analyzer case studies are included in data base in addition to trials

[mmmp.org]

Standardized semantics impossible (discussion)